Carcinogenic and Chronic Toxic Hazards of Aromatic Amines
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چکیده
منابع مشابه
N-hydroxylation of carcinogenic and mutagenic aromatic amines.
N-Hydroxylation and mutagenic activation of heterocyclic aromatic amines from protein pyrolysis products were studied in rat liver microsomes and nuclei, rat hepatocytes and various species of purified cytochrome P-450. These mutagenic amines include Trp-P-2 (3-amino-1-methyl-5H-pyrido[4,3-b]indole), Trp-P-1 (3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole), Glu-P-1 (2-amino-6-methyldipyrido-[1,2-a...
متن کاملIn Vitro Metabolism and Activation of Carcinogenic Aromatic Amines by Subcellular Fractions of Human Liver1
In vitro metabolism and metabolic activation of 2-acetylaminofluorene (AAF), 2-aminofluorene, and 2,4-diaminoanisole to mutagenic (Salmonella test system) and covalently proteinbound intermediates were evaluated in subcellular fractions from seven human livers. The cytochrome P-450 content, aryl hydrocarbon hydroxylase activity, and sodium dodecyl sulfate: polyacrylamide gel electrophoresis of ...
متن کاملIn vitro metabolism and activation of carcinogenic aromatic amines by subcellular fractions of human liver.
In vitro metabolism and metabolic activation of 2-acetylaminofluorene (AAF), 2-aminofluorene, and 2,4-diaminoanisole to mutagenic (Salmonella test system) and covalently proteinbound intermediates were evaluated in subcellular fractions from seven human livers. The cytochrome P-450 content, aryl hydrocarbon hydroxylase activity, and sodium dodecyl sulfate: polyacrylamide gel electrophoresis of ...
متن کاملMetabolic Activation of Carcinogenic Aromatic Amines by Dog Bladder and Kidney Prostaglandin H Synthase1
Microsomal enzyme preparations from dog liver, kidney, and bladder were used to assess the prostaglandin H synthasecatalyzed activation of carcinogenic aromatic amines to bind covalently to proteins and nucleic acids. Benzidine, a urinary bladder carcinogen, bound to protein of bladder transitional epithelial and renal inner and outer medullary microsomes and was dependent upon addition of arac...
متن کاملBladder and Kidney Prostaglandin H Synthase Metabolic Activation of Carcinogenic Aromatic Amines by Dog
Microsomal enzyme preparations from dog liver, kidney, and bladder were used to assess the prostaglandin H synthasecatalyzed activation of carcinogenic aromatic amines to bind covalently to proteins and nucleic acids. Benzidine, a urinary bladder carcinogen, bound to protein of bladder transitional epithelial and renal inner and outer medullary microsomes and was dependent upon addition of arac...
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ژورنال
عنوان ژورنال: Occupational and Environmental Medicine
سال: 1963
ISSN: 1351-0711
DOI: 10.1136/oem.20.3.251-b